Canine morbidity and mortality due to respiratory disease has impeded medical investigation for many years and continues to be the major obstacle to consistent chronic survival of dogs undergoing research studies. The organism responsible for the majority of contagious respiratory infections in laboratory dogs has been believed to be viral, most frequently the distemper virus. Other viruses, such as canine herpes, hepatitis, and adenovirus, may also initiate respiratory infections but less commonly. Little attention has been directed to secondary bacterial respiratory infections which frequently follow mild canine viral infections. These bacterial infections appear to be much more likely to cause morbidity and mortality than do primary viral infections.
The present investigation was undertaken to survey viral and bacterial flora from the respiratory tracts of dogs newly admitted to the UCLA Animal Facility. An antibiotic sensitivity analysis from each bacterial culture was carried out in order to develop a rational antibiotic
Snow HD, Donovan ML, Washington JO, Fonkalsrud EW. Canine Respiratory Disease in an Animal FacilityViral and Bacteriological Survey. Arch Surg. 1969;99(1):126–128. doi:10.1001/archsurg.1969.01340130128027