The exact sequence of events that leads to death in acute hemorrhagic pancreatitis has, as yet, not been fully defined in either the clinical form that occurs in humans or in the various types of experimental preparations that have been used by numerous investigators to produce the disease. This multiplicity of experimental methods that has been used to produce hemorrhagic necrosis of the pancreas has compounded the problem by fostering attempts to relate widely varying etiological factors to a common denominator, ie, death.
The pancreatic enzymes have been implicated in most forms of experimentally induced pancreatitis as being one of the major factors or the major factor affecting morbidity and mortality. Most of these studies have been made of the effect of trypsin acting singly or in combination with other experimental factors.1-6 These and other authors have found that trypsin (or a very similar type of enzyme) is either
Rittenbury MS, Hanback LD. Snake AntiveninEffect on Survival Time in Experimentally Induced Hemorrhagic Pancreatitis. Arch Surg. 1969;99(2):179-184. doi:10.1001/archsurg.1969.01340140051008