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November 1969

Enlarging the Lumen of the Carotid SinusAn Experimental Treatment of Systemic Arterial Hypertension

Author Affiliations

From the Department of Surgery, School of Medicine, Johns Hopkins University, Baltimore.

Arch Surg. 1969;99(5):624-627. doi:10.1001/archsurg.1969.01340170076017

The important role of the carotid sinus pressure receptors in regulating the systemic arterial blood pressure has long been recognized.1-3 These pressure sensors are stretch receptors in the wall of the carotid sinus and they relay their stimulating signal by way of the carotid nerve to the vasomotor center in the hypothalamus. These impulses have an inhibitory effect on the vasomotor center leading to vasodilation and decrease in heart rate, cardiac output, venous return, and blood pressure. The stretch placed on these pressoreceptors depends on the wall stress as determined by Laplace's equation.3 The Laplace equation states that T = PR, where T is circumferential wall tension, P is internal distending pressure, and R is radius. Though strictly applicable only for tubes with infinitely thin walls, it provides a basis for understanding the effect of varying the diameter of an artery on the circumferential wall tension. An increase in

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