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November 1969

Further Studies on Vascular Pressure Changes With Overtransfusion

Author Affiliations

From the Department of Surgery and the Heart Research Center, Indiana University School of Medicine, Indianapolis.

Arch Surg. 1969;99(5):628-630. doi:10.1001/archsurg.1969.01340170080018

The measurement of central venous pressure and of left atrial pressure has proved a valuable adjuvant with respect to the administration of blood and other fluids intravenously and as an index of the state of volemia.1-3 Though such determinations generally prove most helpful, they may result in disastrous errors if utilized blindly without regard to other pertinent observations.4 It is for this reason the search has continued for more universally reliable guides.

In a recent study from this laboratory, disappointing results were obtained in experiments carried out upon "closed-chest" dogs both in a healthy state and after having been subjected to "irreversible" shock.5 A 40% decrease or increase in blood volume produced only transient alterations in right atrial, left atrial, and pulmonary artery pressures; and these measurements did not provide a reliable indication of the state of volemia.

Since we recognized that the dog apparently has an

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