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November 1969

Erythropoietin Activity in Autotransplanted Canine Kidneys

Author Affiliations

From the Regional Center New York State Kidney Institute, Department of Urology, Roswell Park Memorial Institute, New York State Department of Health, Buffalo.

Arch Surg. 1969;99(5):660-663. doi:10.1001/archsurg.1969.01340170112027

The kidney is now acknowledged to be the major site of the production or activation or erythropoietin (ESF) which is active in the regulation of normal red blood cell production.1 This hormone is known to be released in response to a variety of stimuli which include bleeding, hypoxic hypoxia, exogenous androgen, or cobalt chloride administration.2 Following successful renal transplantation in the anephric patient, ESF is produced in association with the restoration of normal hematological values.3 The purpose of the present investigation was to determine the ability of canine kidney autotransplants to respond to known ESF stimuli such as bleeding, hypoxic hypoxia, androgen and cobalt administration.2

Materials and Methods  Sixteen healthy male and female mongrel dogs weighing about 18.2 kg (40 lb) were used. Bilateral nephrectomy was performed with the dogs under anesthesia with intravenously administered pentobarbital sodium (30 mg/kg). A single kidney was anastomosed with the

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