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January 1970

Solid Organ Injuries in VietnamEmergency Hemostasis With N-Butyl Cyanoacrylate Adhesive

Author Affiliations

Washington, DC
From the Division of Surgery (Drs. Heisterkamp, Vernick, and Matsumoto), Walter Reed Army Institute of Research, Washington, DC. Dr. Simmons is now with the University of Minnesota Medical School, Minneapolis, and Dr. Matsumoto is now at Hahnemann College of Medicine, Philadelphia.

Arch Surg. 1970;100(1):109-112. doi:10.1001/archsurg.1970.01340190111026

The military surgeon occasionally encounters extensive combat wounds of the liver, kidney, or retroperitoneal area where conventional techniques of hemostasis are not adequate. Consequently, extensive resections of the liver, loss of a kidney, or even death may result. At the very least, considerable effort, time and blood are expended in the combat situation where all three are in short supply.

The present report describes the clinical trial of an aerosol tissue adhesive spray developed by the US Army for use in achieving rapid hemostasis of the solid organs of combat casualties. The development and experimental testing of these materials has been reported by Leonard et al1,2 and Matsumoto and co-workers.3-5

Method  N-Butyl cyanoacrylate is packaged in sterile disposable bottles as a 25% solution in a liquid propellant (carbon tetrafluoride [Freon 14] and dichlorodifluoromethane [Freon 12]). This provides a controllable spray of variable particle size, depending on the rate

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