Hyperamylasemia is known to occur in a number of conditions which may be unrelated to pancreatic disease. Perforated peptic ulcers, mesenteric and portal venous thrombosis, acute cholecystitis, and intestinal obstruction are among the conditions in which amylase and lipase levels in the blood may rise, sometimes without recognizable evidence of pancreatitis.1-8 The mechanism of this elevation and the route by which the enzymes reach the blood stream remain controversial.
In view of the above experiences, this series of experiments in dogs was designed to produce intestinal obstruction and common bile duct obstruction, respectively, and to investigate the resultant changes in the concentrations of amylase and lipase in the serum and in the lymph draining the obstructed area.
Since it was not possible to cannulate the same lymphatic twice so as to permit each animal to serve as his own control, the results of an earlier series of studies were
Singh H, Pepin J, Appert HE, Páirent FW, Howard JM. Amylase and Lipase Secretion in the Hepatic and Intestinal LymphIII. Studies Involving Obstruction of the Small Intestine or Bile Duct in Dogs. Arch Surg. 1970;100(3):253-256. doi:10.1001/archsurg.1970.01340210029009