Even though whole blood may be unavailable in the presence of massive hemorrhage, maintenance of an adequate circulating plasma volume is mandatory. Utilizing an experimental model in which hemorrhage was corrected immediately with equal volumes of plasma substitutes, several adaptive mechanisms occurring in dogs during severe, acute hemodilution have been described.1-3 The observed compensatory increase in cardiac index may have been related partially to hypervolemia. Although several investigators have shown that plasma volume is greater than predicted following the infusion of dextrans of various molecular weights into normovolemic4-7 or hypovolemic subjects,8,9 little information is available concerning the origin of the fluid entering the intravascular space, or the changes occurring within the interstitial space.
Because hydroxyethyl starch is more stable and less expensive to produce than dextran 75, it is currently under investigation as a colloidal plasma substitute. Two main purposes distinguish this paper from our previous work:
Takaori M, Safar P, Galla SJ. Changes in Body Fluid CompartmentsDuring Hemodilution With Hydroxyethyl Starch and Dextran 40. Arch Surg. 1970;100(3):263-268. doi:10.1001/archsurg.1970.01340210039011