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June 1970

Arterial Embolism, Myoglobinuria, and Renal Tubular Necrosis

Author Affiliations

New York
From the Vascular Service, Surgical Division, Montefiore Hospital and Medical Center, Bronx, NY.

Arch Surg. 1970;100(6):639-645. doi:10.1001/archsurg.1970.01340240007002

Four cases of acute arterial occlusion of the lower extremity associated with massive ischemic myopathy and myoglobinuria are reported. Clinically, there were four characteristic manifestations: excruciating pain; severe and extensive ischemia of the tissues; rigidity of the extremity with stiffness of joints; and massive edema. The widespread ischemic myopathy of the extremity is a probable underlying cause of the severity of the local signs. Myoglobinuria was found in the four cases and accounts for the fatal tubular necrosis (myoglobinuric nephrosis) in two patients.