The pulmonary hemodynamic effects of direct pulmonary arterial infusion of fresh autogenous serum and plasma have been measured in four patients and calculated in terms of pulmonary vascular resistance with no differences noted, thus suggesting a lack of importance of a serum-serotonin factor in human pulmonary embolism.
Daily PO, Ranniger K, Zajtchuk R, Evans RE, Moulder PV. Serum and Plasma Infusion in Human Pulmonary ArteryEmbolic Implications. Arch Surg. 1970;101(1):26-31. doi:10.1001/archsurg.1970.01340250028007