July 1970

Evaluation of the Transplanted Lung With Angiography and Xenon 133 Scanning

Author Affiliations

San Diego, Calif; Chapel Hill, NC
From the Department of Surgery, University of California, San Diego (Mr. Walker and Dr. Hutchin), and the Department of Radiology, University of North Carolina, Chapel Hill (Dr. Gabriele).

Arch Surg. 1970;101(1):56-61. doi:10.1001/archsurg.1970.01340250058013

The sequential changes occurring in pulmonary angiograms and xenon 133 scans during unmodified canine lung allograft rejection were compared. In angiograms, there was a minimal prolongation of the duration of the arterial phase and changes in angioarchitecture of the graft four to six days after transplantation. In lung scans, there was an accompanying decrease in ventilation and perfusion. After six days, angiographic and scanning parameters showed rapid deterioration of function in the transplanted lung. Pulmonary scanning after intravenous administration of xenon 133 should provide a convenient method for continuous evaluation of the functional changes in the transplanted lung, while angiography should be reserved for the differential diagnosis of impaired function.