August 1970

Relationship of Hyperparathyroidism to Peptic Ulcer

Author Affiliations

Akron, Ohio
From the Surgical Research Department of Akron City Hospital, Akron, Ohio.

Arch Surg. 1970;101(2):193-199. doi:10.1001/archsurg.1970.01340260097015

Endogenous hyperparathyroidism was produced in inbred rats and the effect on gastric acid and mucus secretion and mucosal ulceration studied. There was no alteration in gastric acidity except during the period of marked hypercalcemia, when it was slightly decreased. Gastric mucus secretion decreased in 73% of the rats. Twenty-seven percent of the animals developed mucosal ulcerations. In the absence of gastric hypersecretion, it is suggested that decrease in mucus secretion may play a role in the defense mechanism against peptic ulceration in association with hyperparathyroidism.