Through studies of the distribution of HL-A antigens in a family and related donor selection on the basis of genotyping, excellent results have been achieved in cases of donor-recipient HL-A identity. Similar good results may be achieved in cases of donor-recipient monoallelic compatibility where the donor's nonshared allele is not associated with a major detectable HL-A antigen. In instances of monoallelic incompatibility where donor's nonshared allele is associated with a single detected HL-A antigen, the individual "strengths" of these antigens can be estimated on the basis of the clinical course of the recipient and studies of renal function and histology.
Jonasson O, Lichter EA, Hamby WM, Smith RD, Gantt CL, Nyhus LM. Donor Selection for Renal Transplantation Based on Genotypic Analysis of HL-A in a Family. Arch Surg. 1970;101(2):219-225. doi:10.1001/archsurg.1970.01340260123020