October 1970

Mobilization of Lipids by Perfusion of Pancreatic Juice in Hind Limbs of Dogs

Author Affiliations

From the departments of surgery (Drs. Yacoub and Howard), physiology (Dr. Appert), and biological chemistry (Dr. Pairent), Hahnemann Medical College and Hospital, Philadelphia.

Arch Surg. 1970;101(4):495-499. doi:10.1001/archsurg.1970.01340280047012

The infusion of pancreatic juice intravenously caused a drop in total lipid levels in serum. The intra-arterial perfusion of both nonactivated and activated pancreatic juice produced a rise in the perfusate levels of lipids. The mechanisms by which pancreatic juice causes a drop in systemic lipid levels while causing an elevation of lipid levels in the perfused hind limb remains unexplained. The perfusion of the juice produced no recognizable ill effects on the perfused limb.