December 1970

Streptokinase for Chronic Arterial Occlusive Disease

Author Affiliations

From the departments of surgery, medicine, and radiology, Tufts University School of Medicine, and the Lemuel Shattuck Hospital, Boston.

Arch Surg. 1970;101(6):653-657. doi:10.1001/archsurg.1970.01340300009003

Infusions of streptokinase (Streptase [Germany]) in 15 patients with chronic occlusions and stenosis of aorta, iliac, and femoral arteries resulted for some in less claudication, better treadmill performance, return of pulses, and improved appearance of arteriograms. Proximal short stenotic lesions respond more favorably than distal long occlusive ones. Complications of thrombolytic therapy did not preclude surgery where this was indicated.