March 1971

Experimental Sphincter for Short-Bowel Syndrome

Author Affiliations

Fort Collins, Colo
From the Surgical Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins. Dr. Grier was a Public Health Service postdoctoral research fellow supported by grant GM36543. He is now at the College of Veterinary Medicine, Iowa State University, Ames.

Arch Surg. 1971;102(3):203-208. doi:10.1001/archsurg.1971.01350030041011

An intraluminal sphincter was constructed by invagination of an everted portion of the distal small intestinal segment into the proximal intestinal segment in nine dogs after 80% distal small intestinal resection. Six dogs with similar resections but no artificial sphincters were used as controls. If the invaginated portion was uniform and at least 1 cm in depth, intestinal transit was retarded. Ability to slow the loss of body weight was related to the competence of the sphincter. Use of the sphincter to retard bowel transit was not without complications: (a) Gastric ulcers developed in some dogs and occult blood was found in the stool. (b) Secondary anemia occurred. (c) Steatorrhea was intensified. It was thought to be due to excessive bacterial proliferation from colonic reflux and stasis proximal and distal to the sphincter.