Analyses were made of changes in the coagulation factor and clinical morbidity in 40 patients with severe trauma. The coagulation tests were determinations of platelet counts, Quick prothrombin time, activated partial thromboplastin time, coagulation factor I, II, V, VII, VIII, IX, X, plasminogen, euglobulin clot lysis, plasminogen activator, plasmin, and fibrin degradation products. Good correlation was found between the severity of the morbidity and a decrease in platelets, factors II and V, and plasminogen, and an increase in fibrin degradation products. The changes in factors I and VIII and in the Quick prothrombin time and partial thromboplastin time correlated poorly with the severity of the patient's illness.
String T, Robinson AJ, Blaisdell FW. Massive TraumaEffect of Intravascular Coagulation on Prognosis. Arch Surg. 1971;102(4):406-411. doi:10.1001/archsurg.1971.01350040168032