In a group of 82 primary gastric ulcer patients with no associated duodenal ulcer disease, ten patients were found with a fasting 12-hour nocturnal gastric secretion of more than 30 mEq of hydrochloric acid. Upon examination of these ten hypersecreting patients, nine had lesser curvature ulcers and one had an ulcer on the greater curvature. Three patients showed some evidence of gastric stasis on the routine barium x-ray film of the gastrointestinal tract. All ten had partial gastric resections but only five had supplementary vagotomy. While no marginal ulcers have developed in the relatively short follow-up period, it is felt that all patients with known preoperative, fasting gastric hypersecretion should have vagotomy as a part of their original operative procedure.
Dragstedt LR, Lulu DJ, Riley WJ, Lawson LJ. Cephalic Hypersecreting Primary Gastric Ulcer Patients. Arch Surg. 1971;102(5):462-464. doi:10.1001/archsurg.1971.01350050028009