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May 1971

Mode of Action of Acetazolamide on Pancreatic Exocrine Secretion

Author Affiliations

From the departments of surgery (Dr. Sum) and gastroenterology (Dr. Banks), Beth Israel Hospital and Harvard Medical School, Boston.

Arch Surg. 1971;102(5):505-508. doi:10.1001/archsurg.1971.01350050071021

In unanesthetized dogs with chronic gastric and pancreatic fistulas, an intravenous infusion of acetazolamide (Diamox), superimposed on a steady-state infusion of secretin, caused a prompt reduction in the volume and bicarbonate concentration of pancreatic secretion and a delayed reduction in potassium concentration. These changes were not caused by alterations in serum electrolytes or by the development of a metabolic acidosis. The reductions in volume and bicarbonate concentration were too rapid and extensive to be accounted for by compensatory respiratory mechanisms, and hence reflect a direct effect of acetazolamide on pancreatic secretion. Reductions in bicarbonate concentration during the infusion of acetazolamide appeared to bear a physiologic relationship to the induced slower flow rates.