The records, culture material, and autopsy data of 27 patients with Candida septicemia revealed that the overall mortality was 72%, attributed in part to their primary disease as well as to the adverse effects of the Candida sepsis. Twenty-five of the 27 patients received multiple blood transfusions within two weeks of their positive blood cultures. Twenty-five patients had indwelling central venous catheters at the time that their positive Candida blood cultures were drawn. All but one of the entire group received broad-spectrum antibiotics in the two-week period preceding their disseminated candidiasis. These features appeared to be significant predisposing factors and probably account for the increased incidence of Candida septicemia noted in this report.
Williams RJ, Chandler JG, Orloff MJ. Candida Septicemia. Arch Surg. 1971;103(1):8-11. doi:10.1001/archsurg.1971.01350070034006