July 1971

The Peutz-Jeghers SyndromeReport of Two Cases, One With 30-Year Follow-Up

Author Affiliations

Santa Barbara, Calif
From the departments of surgery (Drs. McKittrick and Doane) and medicine (Dr. Lewis), Santa Barbara Medical Clinic, and the Department of Surgery, Santa Barbara Cottage-General Hospitals (Dr. Gerwig), Santa Barbara, Calif.

Arch Surg. 1971;103(1):57-62. doi:10.1001/archsurg.1971.01350070083019

The Peutz-Jeghers syndrome is characterized by intestinal polyposis and mucocutaneous melanin pigmentation. It is inherited as a simple mendelian dominant, but sporadic cases may occur by gene mutation. Polyps are usually present from the gastroesophageal junction to the anus, and are hamartomas with little tendency to malignant degeneration. Recurrent abdominal pain from intussusception is the most frequent symptom, and chronic blood-loss anemia is often pres