Three young male patients developed acute glomerulonephritis and serious hemoptysis. All three had evidence of antiglomerular basement membrane (anti-GBM) antibodies in their serum and native kidneys. The pulmonary hemorrhages ceased after bilateral nephrectomy and splenectomy accompanied by irregular treatment with steroids and other immunosuppressants. Renal homotransplantation was successfully carried out from 95 to 162 days later, after circulating anti-GBM antibodies had disappeared. Two of the homografts were biopsied and the third was removed 20, 34, and 2 months posttransplantation, respectively, and contained little or no immunoglobulin. Therefore, Goodpasture's syndrome does not contraindicate renal transplantation under the stipulated conditions of staged therapy.
Halgrimson CG, Wilson CB, Dixon FJ, Penn I, Anderson JT, Ogden DA, Starzl TE. Goodpasture's SyndromeTreatment With Nephrectomy and Renal Transplantation. Arch Surg. 1971;103(2):283-289. doi:10.1001/archsurg.1971.01350080199031