Anastomosis of the divided abdominal aorta (0.8 to 1.8 mm in diameter) of 52 rats was accomplished either by continuous suture or by application of bucrylate (isobutyl-2-cyanoacrylate) following placement of three stay sutures. One of 24 (4%) anastomoses in the suture group failed, and five of 28 (18%) anastomoses in the tissue adhesive group failed. The remainder of the rats were killed at intervals of 1 to 42 days, and sections from the anastomoses in each group were examined histologically. Degeneration of the media and deposition of calcium was seen in the vessels in the bucrylate group. In addition, a more intense and prolonged foreign-body giant-cell response was noted in comparison to vessels in the suture group.
Souther SG, Levitsky S, Roberts WC. Bucrylate Tissue Adhesive for Microvascular AnastomosisTechnique, Results, and Histologic Evaluation. Arch Surg. 1971;103(4):496-499. doi:10.1001/archsurg.1971.01350100094017