Dogs were prepared each with a Heidenhain pouch and with a vagusdenervated, isolated antrum pouch. Acid production in response to simultaneous stimulation of the intestinal phase of gastric secretion by feeding, and the antral phase by irrigation of the antrum with a solution of acetylcholine was sufficiently greater than the sum of that caused by their individual stimulations, to suggest potentiation of the two mechanisms.
Curt JRN, Isaza J, Woodward ER, Dragstedt LR. Potentiation Between Intestinal and Gastric Phases of Acid Secretion in Heidenhain Pouches. Arch Surg. 1971;103(6):709-712. doi:10.1001/archsurg.1971.01350120073013