Intrasplenic ovarian autotransplantation is associated with significant inhibition of 7,12-dimethylbenz (a) anthracene-produced breast carcinoma in the rat. The mechanism of this inhibition may be related to the position of the transplanted ovary within the portal venous system, allowing initial drainage of ovarian venous efflux through the liver. Hepatic alteration of ovarian hormones could result in changes in hormone concentration within the mammary gland, and this may represent the mechanism of inhibition of tumorigenesis. End-to-side portacaval shunt done simultaneously with intrasplenic ovarian transplantation is also associated with significant inhibition of experimental breast carcinoma. The previously observed inhibition of experimental breast carcinoma by end-to-side portacaval shunt alone has been reconfirmed.
Reichle FA, Gruenstein M, Reichle RM, Meranze DR, Rosemond GP, Shimkin MB. Inhibition of Experimental Mammary CarcinomaAutologous Intrasplenic Ovarian Transplant. Arch Surg. 1972;104(2):206-208. doi:10.1001/archsurg.1972.04180020086017