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Article
February 1972

Extra-Adrenal Pheochromocytoma-Producing EpinephrineIts Physiologic Significance

Author Affiliations

New York
From the Department of Surgery, New York Hospital-Cornell Medical Center (Drs. Mannix and O'Grady), and Mount Sinai Hospital and Medical School (Dr. Gitlow), New York. Dr. Mannix is presently Director of Surgery at St. Francis Hospital, Hartford, Conn.

Arch Surg. 1972;104(2):216-218. doi:10.1001/archsurg.1972.04180020096020
Abstract

Extra-adrenal pheochromocytoma accounts for about 10% of all such tumors. These neoplasms usually produce norepinephrine exclusively, and the patient's symptoms are related to overproduction of norepinephrine. Our patient's symptoms are primarily related to the overproduction of epinephrine. Preoperatively, he was thought to have a left adrenal tumor. At operation, however, the tumor was found to arise from one of the left lumbar sympathetic ganglia. Chemical assay of the tumor confirmed the presence of epinephrine in the extra-adrenal site. We believe this is the first instance where chemical assay has proven the presence of epinephrine in an extra-adrenal location.

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