Eight patients with severe symptoms due to hepatic metastases were treated by hepatic artery ligation and infusion of the distal hepatic arterial system with fluorouracil. Minor deterioration in liver function occurred, which was reversible within nine days. Serial liver scans showed reduction in size of the deposits and tumor necrosis was demonstrated in one patient on liver biopsy. All patients improved considerably in terms of symptoms and seven are still alive and in clinical remission. Significant palliative effects can be achieved by hepatic artery ligation and infusion. Morbidity and mortality are minimal.
Gulesserian HP, Lawton RL, Condon RE. Hepatic Artery Ligation and Cytotoxic Infusion in Treatment of Liver Metastases. Arch Surg. 1972;105(2):280-285. doi:10.1001/archsurg.1972.04180080132022