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September 1972

Renal Transplantation Without Oliguric Acute Tubular Necrosis

Author Affiliations

Rochester, Minn
From the Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Surg. 1972;105(3):427-430. doi:10.1001/archsurg.1972.04180090032008

During a nine-month period, 28 consecutive transplants were performed without a single instance of oliguric acute tubular necrosis. Nineteen kidneys were donated by living relatives, and nine were taken from cadavers, with periods of preservation up to 13 hours. All allografts functioned within 90 minutes, and in no case was dialysis necessary because of acute tubular necrosis. Important factors for early posttransplant function include hydration of donors and recipients with liberal use of diuretics, use of "heart-beating cadavers," removal of the kidney only during active diuresis, a means of preservation in cadaver kidneys, and maintenance of a systemic blood pressure to ensure adequate perfusion of the allograft.