November 1972

Hepatic Congestion and Bile Secretion

Author Affiliations

Brooklyn, NY
From the Department of Surgery, Methodist Hospital of Brooklyn and State University of New York, Downstate Medical Center, Brooklyn, NY.

Arch Surg. 1972;105(5):749-751. doi:10.1001/archsurg.1972.04180110070017

Twenty-four-hour bile flows were measured on eight or more occasions in each of six female dogs with permanent choledochostomy. Average daily flows varied from 125 to 300 ml/24 hr, but were consistent in any one animal. Hepatic congestion was then produced by constricting the thoracic inferior vena cava. Ascites developed in all dogs. Bile flows were measured again at least eight times. There was no significant change in bile flow in five of the six animals; in the sixth there was increased flow after caval constriction. Bile acid (taurocholate) concentrations were minimally affected by hepatic congestion.