Congenital pyloric atresia is a very rare condition and, to our knowledge, has never been described in siblings. Two siblings (a male and a female) are described; the first sibling died from peritonitis, after operation to close gastric perforation. In the other sibling, the diagnosis was made by gastric aspiration of the last feeding just prior to the next, and gastroduodenostomy was successful. The possibility is raised of this being a genetically determined condition.
Tan K, Murugasu JJ. Congenital Pyloric Atresia in Siblings. Arch Surg. 1973;106(1):100-102. doi:10.1001/archsurg.1973.01350130098023