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February 1973

Regional Perfusion With Antibiotics for Chronic Bone Infections

Author Affiliations

From the departments of surgery (Dr. Jones) and preventive medicine and public health (Dr. Barnett), and the Division of Orthopedic Surgery (Dr. Gregory), University of Texas Southwestern Medical School, Dallas.

Arch Surg. 1973;106(2):142-144. doi:10.1001/archsurg.1973.01350140010005

Nine patients with chronic bone infection of the lower limb were treated by isolated regional perfusion with antibiotics. A variety of antibiotics was used, including some with potential systemic toxicity. No significant local or systemic toxicity occurred in this series. Six of the nine patients, who have been followed for periods ranging from nine months to 12 years, show no clinical evidence of residual infection.