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March 1973

Mitomycin and the Healing of Intestinal AnastomosisAn Experimental Study in the Rat

Author Affiliations

Tel Aviv, Israel
From the departments of surgery "A" (Drs. Wiznitzer, Orda, Bawnik, and Rippin) and chemical pathology (Dr. Herzberg), Ichilov Hospital, Tel Aviv University Medical School; and Department of Pathology (Dr. Griffel), Meir Hospital, Tel Aviv (Israel) University Medical School.

Arch Surg. 1973;106(3):314-316. doi:10.1001/archsurg.1973.01350150048013

An experiment on albino rats was conducted in order to study the effect of mitomycin (mitomycin C) on the healing of intestinal anastomoses. In each of four experimental groups, murine therapeutic doses were administered intermittently at different intervals. The healing process at the suture line was examined histologically, tensile strength was measured, and hydroxyproline content was determined. The results were compared with a group of experimental animals who did not receive the drug. No significant difference in the healing of intestinal anastomoses was found in the various experimental groups.