In an attempt to prevent post-traumatic pulmonary insufficiency possibly resulting from massive blood transfusions, 29 trauma cases were studied prospectively. Thirteen patients received from 10 to 63 units of blood through a fine screen filter (Ultipor) consisting of a uniform pore size of 40μ. This group was compared to a control group of 16 patients who received from 10 to 40 units of blood through a standard 170μ blood filter. An average of 19 units of blood was transfused. In the control group eight of 16 patients developed some degree of pulmonary insufficiency. Only two of thirteen developed pulmonary insufficiency in the filter group. These findings correlated well with lung biopsy specimens. It is apparent that one of the mechanisms of post-traumatic pulmonary insufficiency has been altered significantly by the use of the fine screen filter.
Reul GJ, Greenberg SD, Lefrak EA, McCollum WB, Beall AC, Jordan GL. Prevention of Post-Traumatic Pulmonary InsufficiencyFine Screen Filtration of Blood. Arch Surg. 1973;106(4):386-394. doi:10.1001/archsurg.1973.01350160008002