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Article
April 1973

Clindamycin in the Treatment of Soft-Tissue Infections

Author Affiliations

Chicago
From the University of Illinois College of Medicine, Abraham Lincoln School of Medicine, at Veterans Administration West Side Hospital Department of Surgery, Chicago.

Arch Surg. 1973;106(4):578-581. doi:10.1001/archsurg.1973.01350160190033
Abstract

Clindamycin phosphate, a parenteral preparation of the antibiotic clindamycin, was used to treat 131 patients with documented bacterial infections. Clindamycin therapy effectively eradicated 81% of the infections. There were no apparent systemic toxic effects. Injections of clindamycin phosphate were satisfactorily tolerated for as long as three weeks. Resistant Staphylococcus aureus developed in 8% of the cases.

Thus, parenterally administered clindamycin phosphate appears to be safe and effective in treating serious surgical infections due to gram-positive organisms and shows promise in treating anaerobic infections.

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