Wedge-shaped fractures of the tibiae of rats and dogs were locally treated with soluble collagen of pigskin. As a result of this, significantly higher stability levels of the fracture callus were achieved in a shorter time than in controls. Earlier formation of the callus was proved histologically. The serum determinations indicated a mineral deposit on the protein matrix that occurred much sooner than in the control fractures.
Benfer J, Struck H. Experimental Studies on Fracture HealingIII. Accelenrated Fracture Healing Through Soluble Heterologous Collagen. Arch Surg. 1973;106(6):838-842. doi:10.1001/archsurg.1973.01350180072021