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August 1973

Pediatric and Adult PheochromocytomasA Biochemical and Clinical Comparison

Author Affiliations

Ann Arbor, Mich
From the Department of Surgery, University of Michigan Medical Center, and Ann Arbor Veterans Administration Hospital (Dr. Freier), Ann Arbor, Mich.

Arch Surg. 1973;107(2):252-255. doi:10.1001/archsurg.1973.01350200114024

Biochemical and clinical comparison is made between 20 adults with pheochromocytomas and seven pediatric patients with similar tumors studied in a large institution over a 6½-year period.

Differences in urinary catecholamine and metanephrine metabolite values done preoperatively on both groups were compared by Student t test and found to be insignificant. Tissue levels for catecholamines were also compared and found to have no significant difference.

In the clinical comparison, the influence of familial pheochromocytomas is noted and partly explains the incidence of multiple tumors seen in this series of children with pheochromocytomas.

The pediatric pheochromocytoma biochemically, clinically, and histologically is more nearly similar to its adult prototype than to less differentiated neural crest tumors such as neuroblastomas.