Biochemical and clinical comparison is made between 20 adults with pheochromocytomas and seven pediatric patients with similar tumors studied in a large institution over a 6½-year period.
Differences in urinary catecholamine and metanephrine metabolite values done preoperatively on both groups were compared by Student t test and found to be insignificant. Tissue levels for catecholamines were also compared and found to have no significant difference.
In the clinical comparison, the influence of familial pheochromocytomas is noted and partly explains the incidence of multiple tumors seen in this series of children with pheochromocytomas.
The pediatric pheochromocytoma biochemically, clinically, and histologically is more nearly similar to its adult prototype than to less differentiated neural crest tumors such as neuroblastomas.
Freier DT, Tank ES, Harrison TS. Pediatric and Adult PheochromocytomasA Biochemical and Clinical Comparison. Arch Surg. 1973;107(2):252-255. doi:10.1001/archsurg.1973.01350200114024