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September 1973

Inhibition of Renal Allograft RejectionInstances in Dogs With Specific Enhancing Immunoglobulin and Its Proteolytic Fragments

Author Affiliations

Duarte, Calif
From the Department of General and Oncologic Surgery, City of Hope National Medical Center, Duarte, Calif.

Arch Surg. 1973;107(3):390-394. doi:10.1001/archsurg.1973.01350210026009

Dog-specific IgG and Fab was produced from dogs immunized against donor dog's spleen and kidney. Goat antidog kidney F(ab′)2 was secured by immunizing goats against donor dog's kidney. These specific enhancing immunoglobulin and proteolytic fragments were perfused intrarenally via the renal artery following the renal allograft made in the neck. Dogs treated with IgG survived on the average of 9.9 days, whereas the mean survival time of five dogs treated with Fab was 5.6 days, excluding one longterm survivor of 31 days. Dogs receiving goat F(ab′)2 had a mean survival time of 11.0 days, which was not statistically significant when compared with control dogs with MST of 8.7 days. Although F(ab′)2 has been successfully utilized to prolong renal allografts in other experimental models, we have not been able to achieve enhancement in our canine model system.