An animal model has been developed to study several factors which, in the clinical setting, are frequently found to be associated with "stress bleeding." The effects of negative nitrogen balance, recumbency, and indwelling Levin tube each have been evaluated singly and in various combinations. Singly, these insults did not significantly affect the gastric mucosa. In various combinations, however, they produced a clear-cut and sometimes florid picture of erosion gastritis and esophagitis. These adverse mucosal changes were prevented in animals in which the negative nitrogen balance was corrected by hyperalimentation, and gastrostomy was used in lieu of Levin tube drainage.
Carrasquilla C, Weaver A, Amarasinghe DC, Rota A, Walt AJ. Gastroesophageal Erosions and UlcerationsExperimental Studies. Arch Surg. 1973;107(3):447-451. doi:10.1001/archsurg.1973.01350210077020