Fifteen squamous cell carcinomas of the skin, termed inadequately excised by the pathologist, were aggravated by lack of patient cooperation or availability. If there was no prophylactic treatment, a recurrence rate of about 50% and an ultimate patient mortality of about 25% from uncontrolled cancer was observed.
Prophylactic retreatment with reexcision or radiotherapy before the appearance of clinical recurrence in 24 patients significantly reduced these failures.
Glass RL, Perez-Mesa CM. Management of Inadequately Excised Epidermoid Carcinoma. Arch Surg. 1974;108(1):50-51. doi:10.1001/archsurg.1974.01350250042011