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Article
June 1974

Idiopathic Hypoglycemia in InfancySurgical Management

Author Affiliations

Los Angeles
From the departments of surgery (Drs. Fonkalsrud and Trout) and pediatrics (Drs. Lippe, LaFranchi, and Dakake), UCLA School of Medicine, Los Angeles.

Arch Surg. 1974;108(6):801-804. doi:10.1001/archsurg.1974.01350300043012
Abstract

Resection of 75% to 90% of the pancreas is an important measure in the treatment of at least three different β-cell disorders that produce severe persistent hypoglycemia of infancy. The treatment is associated with low mortality and morbidity and should be undertaken early to obviate the not infrequent occurrence of mental retardation.

Of three infants described herein who underwent subtotal pancreatectomy for idiopathic hypoglycemia, two maintained normal blood glucose levels postoperatively without further therapy. The third required cortisone administration for four years, after which the blood glucose level was maintained innormal range without therapy. The resected pancreas in two patients showed islet cell hyperplasia; in one of these, an unusual budding of islet cells (nesidioblastosis) was found. In one patient, the resected pancreas was normal histologically. Two patients have no apparent brain damage, and one has mild retardation.

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