[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.159.158.180. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 1974

Reversal of Colonic Net Absorption to Net SecretionWith Increased Intraluminal Pressure

Author Affiliations

New Haven, Conn
From the Department of Surgery, Yale University, School of Medicine, New Haven, Conn. Dr. Bury is now with Wellesley Hospital, Toronto.

Arch Surg. 1974;108(6):854-857. doi:10.1001/archsurg.1974.01350300086020
Abstract

The effect of increased intracolonic pressure on net water, sodium, and unidirectional sodium movement in the ascending colon of adult rats was measured. With elevations of intraluminal pressure from control values of 4 to 30 mm saline, a rapid reversal of net absorption to net secretion occurred; this increased over the next hour, although the pressure was kept stable. Increases in the exsorption or blood-to-lumen movement of sodium were the main reasons for the net secretion observed; it is suggested that an increased intraluminal pressure is transmitted across the mucosa, causing an increase in mucosal interstitial pressure with a diffusion of isotonic saline into the lumen in response to this gradient.

×