Microcrystalline collagen hemostat (Avitene) is a new surface hemostatic agent that is useful in the control of bleeding from the surfaces of solid viscera. In this study its efficacy was studied in experimental splenic injuries produced in dogs. Surface hemostasis obtained with this material appeared more effective and reliable than with other traditional hemostatic agents (absorbable gelatin sponge). Within five minutes of application to a surface splenic injury, complete hemostasis was obtained in 50 instances. No delayed bleeding was observed in any of the experimental subjects, nor were there other untoward reactions such as infection or excessive adhesion formation. Microcrystalline collagen is absorbed within six weeks, with minimal tissue reaction. The material was used successfully in one human case of iatrogenic splenic injury during a gastric procedure, averting splenectomy. No complications ensued.
Morgenstern L. Microcrystalline Collagen Used in Experimental Splenic InjuryA New Surface Hemostatic Agent. Arch Surg. 1974;109(1):44-47. doi:10.1001/archsurg.1974.01360010030006