[Skip to Content]
[Skip to Content Landing]
July 1974

Ovariectomy in Rats With Portacaval ShuntsReduction of Mammary Carcinoma

Author Affiliations

From the Department of Surgery, Agnes Barr Chase Surgical Research Laboratory, and Fels Research Institute, Temple University Health Sciences Center, Philadelphia. Dr. O'Grady is presently with the Department of Surgery, University College and St. Vincent's Hospital, Dublin.

Arch Surg. 1974;109(1):87-88. doi:10.1001/archsurg.1974.01360010065016

A reduced incidence of 9,10-dimethyl-1,2-benzanthracene (DMBA)-produced breast carcinoma has been demonstrated in rats having an end-to-side portacaval shunt. As the liver plays an important part in estrogen metabolism, the growth of established breast carcinoma in rats with and without a portacaval anastomosis was studied after bilateral ovariectomy was performed in both groups. Average increase in tumor size at death or one year after DMBA was 2.48 ±0.57 cm for rats with no shunt (sham operation) and 0.82 ± 0.39 cm for rats with a shunt (P<.05). Following bilateral ovariectomy, the suppression of DMBA-produced mammary carcinoma growth was significantly greater in the rats with a portacaval shunt.