In 65 patients, split-thickness donor sites were covered with amniotic membrane. Amniotic membrane was used to dress partialthickness burns in 42 patients. In rats, open wounds were covered with amnion and in others it was placed in a subcutaneous pocket. The amnion acted as a comfortable and effective wound dressing. None of the biopsy specimens, however, showed vascularization of the amnion by the host.
Colocho G, Graham WP, Greene AE, Matheson DW, Lynch D. Human Amniotic Membrane as a Physiologic Wound Dressing. Arch Surg. 1974;109(3):370-373. doi:10.1001/archsurg.1974.01360030022006