September 1974

Human Amniotic Membrane as a Physiologic Wound Dressing

Author Affiliations

From the General Clinical Research Center of the Graduate Hospital, Philadelphia (Drs. Colocho and Lynch); the departments of surgery and anatomy, Milton S. Hershey Medical Center of the Pennsylvania State University, Hershey, Penn (Drs. Graham and Matheson); and the Institute for Medical Research, Camden, NJ (Dr. Greene).

Arch Surg. 1974;109(3):370-373. doi:10.1001/archsurg.1974.01360030022006

In 65 patients, split-thickness donor sites were covered with amniotic membrane. Amniotic membrane was used to dress partialthickness burns in 42 patients. In rats, open wounds were covered with amnion and in others it was placed in a subcutaneous pocket. The amnion acted as a comfortable and effective wound dressing. None of the biopsy specimens, however, showed vascularization of the amnion by the host.