Models of mouse heparinization (to a bleeding time of over 2½ times control, by the "farmer's wife" technique) and pulmonary contusion (by water blast) are described. Four groups of ten mice each received pulmonary contusion. One group was not anticoagulated, another group was anticoagulated immediately precontusion, the third group was anticoagulated immediately postcontusion, and the last group was anticoagulated 24 hours after contusion. All were examined at death or killed and examined 48 hours after contusion. There was no difference in mortality or size of the pulmonary lesion among the four groups.
This study suggests that anticoagulation will not prove hazardous in patients with pulmonary contusion in whom anticoagulation is indicated for associated lesions.
Ratliff JL. The Risk of Anticoagulation With Experimental Pulmonary Contusion. Arch Surg. 1974;109(6):802-804. doi:10.1001/archsurg.1974.01360060072019