Because of its rarity, the diagnosis of peripheral vascular ischemia secondary to ergotamine administration can be easily overlooked with serious irreversible consequences. A patient required treatment for ischemia of the left leg found to be caused by excessive use of an ergotamine tartrate suppository prescribed for migraine headaches. The angiographic characteristics of vessels during ergot intoxication include bilateral and symmetrical arterial spasm, collateralization, and, infrequently, thrombi formation.
Ancalmo N, Ochsner JL. Peripheral Ischemia Secondary to Ergotamine Intoxication. Arch Surg. 1974;109(6):832-834. doi:10.1001/archsurg.1974.01360060098027