Ninety-five patients who underwent bilateral adrenalectomy for metastatic breast carcinoma are reviewed. An objective remission of tumor was observed in 66% of the patients over the age of 45 years with metastasis limited to soft tissue, osseous, or pulmonary system. In those patients below the age of 45, only 19% had remission irrespective of the sites of metastasis.
Thirty-three patients were admitted with no "free interval," with objective remission occurring in 42%. This observation indicates that the "free interval" is not as striking a determinant in selecting adrenalectomy candidates as had been stressed by others.
The serial treatment of adrenalectomy followed by chemotherapy after adrenalectomy failure or relapse was shown to objectively benefit 74% of 72 patients evaluated. Sulfokinase activity in breast cancer tissue was studied in 17 patients. The results were not as definitive as reported by others.
Brown PW, Terz JJ, King R, Lawrence W. Bilateral Adrenalectomy for Metastatic Breast Carcinoma. Arch Surg. 1975;110(1):77-81. doi:10.1001/archsurg.1975.01360070077013