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In Reply.—The rats were fed ordinary rat chow ad lib, and no attempt was made to pair-feed. Experimental animals had lost about 20% of their initial weight at the time of killing; whereas sham animals gained weight normally. The point of the experiment, however, is precisely as stated in the first paragraph of the letter from Dr Young. It may be considered well established by three laboratories working independently (references in original communication) that pancreatobiliary secretions have a trophic effect on the intestinal mucosa. Our experiment was designed to get at the question of whether or not these secretions are an absolute requirement for adaptive growth, irrespective of nutritional condition. After bypass of these secretions to the colon, there was still evidence of compensatory hypertrophy. This observation is in the opposite direction of any effect of malnutrition of which we are aware. The effect of starvation on the gut
TILSON MD. Compensatory Hypertrophy of the Ileum-Reply. Arch Surg. 1975;110(8):1049. doi:10.1001/archsurg.1975.01360140193040