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October 1975

Subcutaneous Angiolymphoid Hyperplasia (Kimura Disease)Report of a Case

Author Affiliations

From the departments of surgery (Drs Sithian and Cucolo) and pathology (Dr Kim), Lutheran Medical Center, Brooklyn, NY.

Arch Surg. 1975;110(10):1246-1248. doi:10.1001/archsurg.1975.01360160084015

A subcutaneous mass removed from the cheek showed histologic features of subcutaneous angiolymphoid hyperplasia (Kimura disease) at its early stage. The condition shows a wide spectrum of pathologic changes. At its early stage, the main findings consist of active vascular proliferation with plump endothelial cells and varying degrees of lymphocytic, histiocytic, and eosinophilic infiltration. The lesion at its later stage features hyperplastic blood vessels with inconspicuous endothelial cells, well-formed lymphoid follicles, and varying degrees of lymphocytic and eosinophilic infiltration. Blood eosinophilia is frequently seen.

Review of the literature and study of our own case strongly suggest that this disease is a distinct clinical and pathologic entity.