To the Editor.—I am responding to the article by Brown et al, entitled "Bilateral Adrenalectomy for Metastatic Breast Carcinoma" (Arch Surg 110:77-81, 1975). Several of their findings were in agreement with our published results, as listed below:
Sulfokinase activity in breast cancer tissue is not a good predictive index for adrenalectomy.1 Since our preliminary report, more than 56 patients have been evaluated; results were not encouraging.
In evaluating 119 patients who had undergone adrenalectomy in our institution, we did not find any correlation of a tumor-free interval to subsequent response to adrenalectomy. Forty percent of the patients with tumor-free intervals of less than one year had responded to adrenalectomy, compared with 47% to 48% of patients with longer tumor-free intervals.1 However, other clinical criteria, such as age, menopausal status, and cytohormonal evaluation, are of minor importance in relationship to subsequent clinical response to adrenalectomy.
LEUNG BS. More on Adrenalectomy for Metastatic Breast Cancer. Arch Surg. 1975;110(12):1517. doi:10.1001/archsurg.1975.01360180087023